AbstractRetinal organoids (ROs) offer a biomimetic in vitro model for investigating human retinal development and disease. However, current ROs face several limitations, such as the absence of vascula...

ABSTRACT: Corneal damage-related disorders, characterized by stromal opacity due to trauma, infection, or other etiologies, remain a major cause of visual impairment. Despite therapeutic advances, the...

ABSTRACTThe oxidative stress-induced degeneration of the retinal pigment epithelium (RPE) and secondary photoreceptor damage are the main causes of dry agerelated macular degeneration (AMD). No effec...

Abstract Sleep apnea that leads to chronic intermittent hypoxia (CIH) is an independent risk factor for advanced, debilitatingischemic proliferative retinopathies, such as diabetic retinopathy (DR) an...

AbstractPURPOSE. The purpose of this study was to understand how the gut microbial system responds to retinal injury. METHODS. Adult C57BL/6J mice were subjected to retinal laser burns or hypotony-ind...

AbstractSjögren's syndrome-related dry eye (SSDE) is a severe dry eye subtype characterized by significant immune cell attacks on the lacrimal gland. However, delivering immunosuppressive drugs to the...

AbstractAge-related retinal degeneration, such as diabetic retinopathy and age-related macular degeneration, are major causes of blindness in modern society. Recent studies suggest that dysbiosis and ...

AbstractKeratoconus (KC) is a prevalent ectatic corneal disease influenced by corneal biomechanics, though its pathogenesis remains unclear. Constructing an in vitro corneal model with adjustable biom...

AbstractBackground Recent advances in clinical trials have involved the transplantation of induced retinal pigment epithelium (iRPE) cells from stem cells in creating a functional monolayer that mimic...

AbstractHigh myopia is a global health concern, often leading to degenerative retinal changes known as myopic retinopathy. Although mechanical stress, hypoperfusion, extracellular matrix remodeling, a...

ABSTRACTPRPF6, located on chromosome 20, is required for the formation of the spliceosome. Mutations in the PRPF6 gene can lead to retinitis pigmentosa (RP), a common inherited retinal disease charact...

AbstractBackground X-linked juvenile retinoschisis (XLRS) is an inherited disease caused by RS1 gene mutation, which leads to retinal splitting and visual impairment. The mechanism of RS1-associated ...

Purpose: To investigate the risk factors for patients with focal choroidal excavation (FCE) and their correlation with chorioretinal diseases.Design: Retrospective cross-sectional study.Subjects: Pati...

AbstractRetinitis pigmentosa (RP) is a common inherited retinal disease characterized by progressive degeneration of the retina, leading to night blindness, progressive vision loss, and constriction o...

AbstractX-linked retinoschisis (XLRS) is a common retinal genetic disease that occurs in juvenile males and causes progressive visual impairment. This presents a schisis in the macula or peripheral re...

AbstractDiabetic keratopathy (DK), a significant complication of diabetes, often leads to corneal damage and vision impairment. Effective models are essential for studying DK pathogenesis and evaluati...

AbstractNeovascular age-related macular degeneration (nAMD) is the leading cause of blindness in the elderly in developed countries. Intravitreal injection of VEGF inhibitors is the mainstream therapy...

AbstractInheritedretinal diseases (IRDs) can induce severe sight-threatening retinaldegeneration and impose a considerable economic burden on patients and society,making efforts to cure blindness impe...

AbstractCornealneovascularization (CNV) is a condition that can severely adversely affectcorneal transparency, culminating in visual disturbances and potentialblindness. The need to manage this condit...

AbstractPurpose: Diabetic retinopathy (DR) is a commoncomplication of diabetes and has a high prevalence. Dysregulation of circadianrhythmicity is associated with the development of DR. This research ...

AbstractBackground: Diabetic retinopathy (DR) developmentis associated with disturbances in the gut microbiota and related metabolites.Butyric acid is one of the short-chain fatty acids (SCFAs), which...

AbstractThethree-dimensional (3D) retinal organoids (ROs) derived from human inducedpluripotent stem cells (hiPSCs), mimicking the growth and development of thehuman retina, is a promising model for i...

AbstractTissueinjury is a common clinical problem, which may cause great burden onpatients' life. It is important to develop functional scaffolds to promotetissue repair and regeneration. Due to their...

AbstractCornealnerve wounding oftencauses abnormalities in the cornea and even blindness insevere cases. In this study, we construct a dorsal root ganglion-corneal stromalcell (DRG-CSC, DS) co-culture...

AbstractPre-mRNAprocessing factors (PRPFs) are vital components of the spliceosome and areinvolved in the physiological process necessary for pre-mRNA splicing to maturemRNA. As an important member, P...

AbstractPropagatinglarge amounts of human corneal stromal cells (hCSCs) in vitro while maintainingthe physiological quality of their phenotypes is necessary for theirapplication in cell therapy. Here,...

AbstractPurpose: This study aimed to determine the effect ofpinacidil, a nonselective KATP channel opener, on diabetes-induced retinalgliosis and inflammation.Methods: Primary and immortalized cell li...

AbstractInvertebrates, most somatosensory pathways begin with the activation of dorsalroot ganglion (DRG) neurons. The development of an appropriate DRG culturemethod is a prerequisite for establishin...

AbstractThepathogenesis of type 2 diabetes mellitus (T2DM) is commonly associated withaltered gut bacteria. However, whether the microbial dysbiosis that exists inhuman diabetic patients with or witho...

AbstractPurposeCornealfibroblast can be transformed into corneal myofibroblasts by TGF-β1. Enhancer of zeste homolog 2 (EZH2)upregulation has been observed in the occurrence of other fibrotic disorder...

AbstractAge-relatedmacular degeneration (AMD) is a common vision-threatening disease. The currentstudy sought to integrate DNA methylation with transcriptome profile to explorekey features in AMD. Gen...

AbstractSuspendedspheroid culture using ultralow attachment plates (ULAPs) is reported to effectcorneal fibroblast reprogramming. Polydimethylsiloxane (PDMS), with hydrophobicand soft substrate proper...

AbstractPurpose: Retinal inflammation is involved in thepathogenesis of several retinal diseases. As one of the core clock genes, Nr1d1 hasbeen reported to suppress inflammation in many diseases. We i...

AbstractAgingis a risk factor for multiple retinal degeneration diseases. Entraining braingamma oscillations with gamma-flicker light (γFL) has been confirmed tocoordinate pathological changes in seve...

AbstractAngiographicallysilent cystoid macular edema (CME) is a rare complication from nab-paclitaxel.Here we report a 45-year-old woman with breast cancer who developed CME afterseveral months of tre...

AbstractTheneuroretina is protected by its own defense system, that is microglia and thecomplement system. Under normal physiological conditions, microglial activationis tightly regulated by the neuro...

AbstractPurpose: We performed a bioinformatictranscriptome analysis to determine the alteration of gene expression betweenthe native retina and retinal organoids in both mice and humans.Methods: The d...

AbstractDiabeticeye disease refers to a group of eye complications that occur in diabeticpatients and include diabetic retinopathy, diabetic macular edema, diabeticcataracts, and diabetic glaucoma. Ho...